Tsunade, one of the legendary Sannin alongside Orochimaru and Jiraiya, is the grand-daughter of the first Hokage and the student of the Third Hokage. She is not only one of the strongest Medical ninja; but is also a deadly fighter thanks to her super-strength and healing techniques. Due to her strength and medical prowess, she became the Fifth Hokage of the Hidden Leaf village.
Another student of the Third Hokage and one of the legendary Sannin, Orochimaru is one of the best villains on the show. His mastery of all the ninja arts and his intelligence, combines with his eagerness to unravel all the secrets of the Ninja world makes him a deadly foe. He has committed a lot of crimes in his days and has attained a kind of immortality by stealing others’ bodies and using them for his own.
The final student of the Third Hokage, Jiraiya was one of the strongest shinobi ever to live and was a mentor to Minato Namikaze (The Fourth Hokage), Nagato and Naruto Uzumaki, who went on to become some of the strongest shinobi ever. His abilities as a sage and his prowess as a ninja earned him the title of the legendary Toad sage, although his sage mode wasn’t perfect, making him one of the strongest characters on Naruto. He even refused to become the Hokage, TWICE, and instead trained two Hokages, which is pretty badass!