4. Sasuke Uchiha
One of the protagonist of the show, Sasuke Uchiha is among the strongest of them all. Due to his brother, Itachi Uchiha’s “betrayal” at a young age, he dedicated his life to becoming strong enough to defeat him. By the time the Fourth World War began, he was strong enough to go up against the members of Akatsuki, fight two Kages at the same time, go head to head with Killer Bee and even defeat and kill Danzo Shimura. As an adult, despite losing his left-arm, he has learned to use one-handed hand seals to perform jutsu. Being the reincarnation of Indra Otsutsuki, his chakra is quite strong as well.
3. Naruto Uzumaki
Naruto Uzumaki is the hero of the show and as such one of the strongest characters ever. Being a descendant of Uzumaki clan and the reincarnation of Asura Otsutsuki, Naruto had huge chakra reserves. Initially, Naruto could not perform a lot of jutsus, but over time he learned a lot of stuff like the summoning technique, his trademark Shadow Clone jutsu, the Rasengan and he even mastered Sage Mode and became friends with Kurama. By the end of the anime, he even gained access to the Six Paths Sage Mode elevating his powers even further.